Perturbing effects of the first four asteroids during their proximities with other numbered minor planets are examined for cases of proximity distances being less than 0.001 AU. From among 32 asteroid pairs examined, there were 13 pairs with perturbing effects on orbital elements larger than 10". Hereby, we encountered the hitherto largest interaction effects, associated with proximities of the minor planets. The very largest changes found are: $\Delta M = +57".93$ and $\Delta \omega= -65"34$ with the asteroid (1023) Thomana at its proximity with (1) Ceres; $\Delta \omega = +55".80$, $\Delta \Omega = -57".50$, $\Delta i = -15".86$ and $\Delta \mu = -0".00068$ with (217) Eudora at its proximity with (3) Juno; $\Delta \varphi = +6".02$ with asteroid (2091) Sampo at its proximity with (1) Ceres.