Let $G$ be an abelian group with identity $e$. Let $R$ be a $G$-graded commutative ring, $M$ a graded $R$-module and $A\subseteq h(R)$ a multiplicatively closed subset of $R$. In this paper, we introduce the concept of graded $A$-2-absorbing submodules of $M$ as a generalization of graded 2-absorbing submodules and graded $A$-prime submodules of $M.$ We investigate some properties of this class of graded submodules.