The Serbian railway Šid - Dimitrovgrad was completed at the end of the 19th century, and besides occasional reconstructions and technological upgrades, it is still in service. The geographical position of the railway route and the historical context at the time of construction and during operation, made that the railway exceeded its local significance and become an important corridor of the European railway network. In recent years, the strategic modernisation of the Serbian railway system, including the Šid - Dimitrovgrad railway, is underway. That is why we have initiated the research of the industrial heritage along the railway, which sometimes dates from the time of construction. Our purpose was to identify, research and document existing railway installations and technical infrastructure, as well as the industrial heritage surrounding the railway.In this article, we present the results of our research and suggest ways to continuously preserve some of the valuable cultural, technical and industrial heritage.