We introduce and study a class of generalized nonlinear vector quasi-variationallike inequalities with set-valued mappings in Hausdorff topological vector spaces which includes generalized nonlinear mixed variational-like inequalities, generalized vector quasi-variational-like inequalities, generalized mixed quasi-variational-like inequalities and so on. By means of fixed point theorem, we obtain existence theorem of solutions to the class of generalized nonlinear vector quasi-variational-like inequalities in the setting of locally convex topological vector spaces.