This article deals with a 2 × 2 reaction-diffusion-taxis model consisting of Michaelis-Menten functional response predator-prey system. The critical section of this model is that temporal-spatial evolution of the predators' velocity depends largely on the gradient of prey. But beyond that, this system also inscribes a prey-taxis mechanism that is an immediate movement of the predator u in response to a change of the prey v (which leads to the collection of u). By using contraction mapping principle, L p estimates and Schauder estimates of parabolic equations, we prove the global existence and uniqueness of classical solutions to this model. In addition to this, we prove the global boundedness of solutions by overcome the difficulties brought by nonlinear prey-taxis.