In this paper, we introduce a new class of submanifolds which are called pointwise quasi bi-slant submanifolds in almost Hermitian manifolds which extends quasi bi-slant, bi-slant, hemi-slant, semi-slant and slant submanifolds in a very natural way. Several basic results in this respect are proved in this paper. Moreover, we obtain some conditions of the distributions which is involved in the definition of the new submanifolds. We also get some results for totally geodesic and mixed totally geodesic conditions for pointwise quasi bi-slant submanifolds. Finally, we illustrate some examples in order to guarantee the new kind of submanifolds.