In this paper, a tumor-immune interaction model has been analyzed via Caputo-Fabrizio fractional derivative operator with exponential kernel. Existence of solution of the model has been established with a fixed-point method and then it demonstrated the uniqueness of solution also. The stability of the model has been analyzed with the help of Hyers-Ulam stability approach and then numerical solution by using the Adam-Basford method. The results are further examined in detail with simulations for different fractional derivative values.