The aim of the paper is to obtain a new version of Serret-Frenet formulae for a quaternionic curve in R 4 by using the method given by Bharathi and Nagaraj. Then, we define quaternionic helices in H named as quaternionic right and left X−helix with the help of given a unit vector field X. Since the quaternion product is not commutative, the authors ([4], [7]) have used by one-sided multiplication to find a space curve related to a given quaternionic curve in previous studies. Firstly, we obtain new expressions by using the right product and the left product for quaternions. Then, we generalized the construction of Serret-Frenet formulae of quaternionic curves. Finally, as an application, we obtain an example that supports the theory of this paper.