The aim of the article is to establish the structure of partial cone b-metric spaces over Banach algebras. Topological and structural properties are investigated of the new spaces. We also define generalized Lipschitz mappings and give their application in fixed point theory. The results presented in this paper substantially extend and strengthen the results of the literature. Few examples are provided to support our conclusions and as an application we establish the existence and uniqueness of a solution to a class of system of nonlinear integral equations