In this work, we define the generalized q-poly-Euler numbers of the second kind of order α and the generalized q-poly-Euler polynomials of the second kind of order α. We investigate some basic properties for these polynomials and numbers. In addition, we obtain many identities, relations including the Roger-Szégo polynomials, the Al-Salam Carlitz polynomials, q-analogue Stirling numbers of the second kind and two variable Bernoulli polynomials