In this paper, we study (1 + 2u + 2v)-constacyclic and skew (1 + 2u + 2v)-constacyclic codes over the ring Z4 + uZ4 + vZ4 + uvZ4 where u2 = v2 = 0,uv = vu. We define some new Gray maps and show that the Gray images of (1 + 2u + 2v)-constacyclic and skew (1 + 2u + 2v)-constacyclic codes are cyclic, quasi-cyclic and permutation equivalent to quasi-cyclic codes overZ4. Further, we determine the structure of (1 + 2u + 2v)-constacyclic codes of odd length n