A discrete-time SIS epidemic model with vaccination is presented and studied. The model includes deaths due to disease and the total population size is variable. First, existence and positivity of the solutions are discussed and equilibria of the model and basic reproduction number are obtained. Next, the stability of the equilibria is studied and conditions of stability are obtained in terms of the basic reproduction number R0. Also, occurrence of the fold bifurcation, the flip bifurcation, and the Neimark- Sacker bifurcation is investigated at equilibria. In addition, obtained results are numerically discussed and some diagrams for bifurcations, Lyapunov exponents, and solutions of the model are presented