In this paper, we introduce anti-invariant Riemannian submersions from nearly-K-cosymplectic manifolds onto Riemannian manifolds. We study the integrability of horizontal distributions. And we investigate the necessary and sufficient condition for an anti-invariant Riemannian submersion to be totally geodesic and harmonic. Moreover, we give examples of anti-invariant Riemannian submersions such that characteristic vector field ξ is vertical or horizontal