Rough set theory is an important tool for data mining. Lower and upper approximation operators are two important basic concepts in the rough set theory. The classical Pawlak rough approximation operators are based on equivalence relations and have been extended to relation-based generalized rough approximation operators. This paper presents topological properties of a pair of relation-based generalized rough approximation operators. A topology is induced by the pair of generalized rough approximation operators from an inverse serial relation. Then, connectedness, countability, separation property and Lindeï of property of the topological space are discussed. The results are not only beneficial to obtain more properties of the pair of approximation operators, but also have theoretical and actual significance to general topology.