E-business technology is becoming one of the most important global markets where e-business solutions will have to adapt to new technologies. The main objective in this study was to synthesize existing knowledge in the field of e-business technology acceptance and to understand differences in Technology Acceptance Model (TAM) related causal effect sizes for different e-business contexts. A quantitative meta-analysis of existing empirical research about factors affecting e-business adoption was conducted using 89 published papers that provided empirical data about causal relationships. A moderator analysis was carried out to investigate the moderating effect of four factors: consumer type, device type, continent and respondent type. The results of the study showed a moderating effect for all four proposed factors in almost all TAM-related causal paths. The study also showed that TAM is the most common theory being applied in e-business adoption research.