During the planning and implementation of Information and Communication Technologies solutions in the healthcare system, attention should be focused on the interests of citizens, healthcare employees, and the public. The project „Development of the Healthcare Information System for Basic Healthcare and Pharmaceutical Services“ demands the implementation of Electronic Healthcare Documentation in the Healthcare Information System of Serbia. This article represents a short overview of previous development of the healthcare information system. Electronic health documentation needs to represent basic health process of every single user. Healthcare Information Systems is based on patients, medical documents, information exchange about patient’s health between health’s, insurances and financials institutions, with primary goal to made healthy population with less cost.